Article
Linkage of osteoporosis to chromosome 20p12 and association to BMP2.
PLoS biology - 1 Dec 2003
Styrkarsdottir Unnur, Cazier Jean-Baptiste, Kong Augustine, Rolfsson Ottar, Larsen Helene, Bjarnadottir Emma, Johannsdottir Vala D, Sigurdardottir Margret S, Bagger Yu, Christiansen Claus, Reynisdottir Inga, Grant Struan F A, Jonasson Kristjan, Frigge Michael L, Gulcher Jeffrey R, Sigurdsson Gunnar, Stefansson Kari
Abstract excerpt
Osteoporotic fractures are a major cause of morbidity and mortality in ageing populations. Osteoporosis, defined as low bone mineral density (BMD) and associated fractures, have significant genetic components that are largely unknown. Linkage analysis in a large number of extended osteoporosis families in Iceland, using a phenotype that combines osteoporotic fractures and BMD measurements, showed linkage to...
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