Article
Thyroid hormone controls the development of connections between the spinal cord and limbs during Xenopus laevis metamorphosis.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2004
Marsh-Armstrong Nicholas, Cai Liquan, Brown Donald D
Abstract excerpt
During premetamorphic stages, Xenopus laevis tadpoles expressing either a dominant-negative thyroid hormone (TH) receptor or a type-III iodothyronine deiodinase transgene in the nervous system have reduced TH-induced proliferation in the spinal cord and produce fewer hindlimb-innervating motorneurons. During prometamorphic stages, innervation of the hindlimbs is reduced, and few functional neuromuscular...
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