Article
The induction of gene mutations and micronuclei by oxiranes and siloranes in mammalian cells in vitro.
Journal of dental research - 1 Jan 2004
Schweikl H, Schmalz G, Weinmann W
Abstract excerpt
Oxiranes and siloranes are candidate molecules for the development of composite materials with low shrinkage. Since some of these molecules are highly reactive, they could lead to adverse biological effects from underlying genetic mechanisms. Therefore, we analyzed the formation of micronuclei (chromosomal aberrations) and the induction of gene mutations (HPRT assay) in mammalian cells. The numbers of micronuclei...
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