Article
The potential genotoxicity of sorbates: effects on cell cycle in vitro in V79 cells and somatic mutations in Drosophila.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Oct 1992
Schlatter J, Würgler F E, Kränzlin R, Maier P, Holliger E, Graf U
Abstract excerpt
Sodium sorbate, potassium sorbate and an oxidation product of sodium sorbate, 4,5-epoxy-2-hexenoic acid, were tested for their genotoxic potential in cultured V79 Chinese hamster cells and in somatic cells of Drosophila melanogaster (wing spot test, SMART). In Drosophila only the epoxide showed a weak genotoxic effect. In V79 cells, freshly prepared sodium sorbate solutions at the highest concentrations only (2.5...
Topics
- Animals
- Cell Cycle
- Cell Line
- Cricetinae
- Cricetulus
- Drosophila melanogaster
- Hydrogen-Ion Concentration
- Mitosis
- Mutagenicity Tests
- Mutagens