Article
Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay.
Nanotoxicology - 1 Jun 2011
Park Margriet V D Z, Verharen Henny W, Zwart Edwin, Hernandez Lya G, van Benthem Jan, Elsaesser Andreas, Barnes Clifford, McKerr George, Howard C Vyvyan, Salvati Anna, Lynch Iseult, Dawson Kenneth A, de Jong Wim H
Abstract excerpt
We investigated the potential of four well-characterized amorphous silica nanoparticles to induce chromosomal aberrations and gene mutations using two in vitro genotoxicity assays. Transmission electron microscopy (TEM) was used to verify the manufacturer's nominal size of 10, 30, 80 and 400 nm which showed actual sizes of 11, 34, 34 and 248 nm, respectively. The 80 (34) nm silica nanoparticles induced...
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