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Article

BRCA1 and BRCA2 protect against oxidative DNA damage converted into double-strand breaks during DNA replication.

DNA repair - 1 Jun 2015

Fridlich Ram, Annamalai Devi, Roy Rohini, Bernheim Giana, Powell Simon N

Abstract excerpt

BRCA1 and BRCA2 mutation carriers are predisposed to develop breast and ovarian cancers, but the reasons for this tissue specificity are unknown. Breast epithelial cells are known to contain elevated levels of oxidative DNA damage, triggered by hormonally driven growth and its effect on cell meta...

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Identifiers

PMID: 25836596
DOI: 10.1016/j.dnarep.2015.03.002
PMCID: PMC4442488

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25836596-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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