Article
Contrasting signaling pathways of alpha1A- and alpha1B-adrenergic receptor subtype activation of phosphatidylinositol 3-kinase and Ras in transfected NIH3T3 cells.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1999
Hu Z W, Shi X Y, Lin R Z, Hoffman B B
Abstract excerpt
Activation of protein kinases is an important intermediate step in signaling pathways of many G protein-coupled receptors including alpha1-adrenergic receptors. The present study was designed to investigate the capacity of the three cloned subtypes of human alpha1-receptors, namely, alpha1A, alph...
Topics
- 3T3 Cells
- Adrenergic alpha-Agonists
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cyclic AMP-Dependent Protein Kinases
- Enzyme Activation
- GTP-Binding Proteins
- Humans
- Mice
- Mutation
- Norepinephrine
- Pertussis Toxin
- Phosphatidylinositol 3-Kinases
- Proto-Oncogene Proteins p21(ras)