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Article

RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures.

BMC cancer - 26 Feb 2014

Andrade Francianne Gomes, Furtado-Silva Juliana Montibeller, Gonçalves Bruno Alves de Aguiar, Thuler Luiz Claudio Santos, Barbosa Thayana Conceição, Emerenciano Mariana, Siqueira André, Pombo-de-Oliveira Maria S

Abstract excerpt

BACKGROUND: Deregulation of the MAPK genes signalling caused by somatic mutations have been implied in leukaemia pathogenesis, including RAS mutation (RASmut) in acute myeloid leukaemia (AML), which has been associated with intra-uterine chemical exposures. A case-case study was conducted in order to explore maternal and child exposures to tobacco smoking associations with early age leukaemia (EAL). METHODS:...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to NAD(P)H Dehydrogenase (Quinone)

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Source

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Identifiers

PMID: 24571676
DOI: 10.1186/1471-2407-14-133
PMCID: PMC3946262

Genes

NQO1
FLT3
KRAS
NRAS

Variants

rs1800566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures.PMID 24571676Read ↗

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