Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of T-786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease.

British journal of haematology - 1 Jan 2004

Sharan K, Surrey S, Ballas S, Borowski M, Devoto M, Wang K-F, Sandler E, Keller M

Abstract excerpt

Acute chest syndrome (ACS) is a life-threatening complication of sickle cell disease (SCD). A retrospective study was performed to evaluate the role of endothelial nitric oxide synthase (eNOS) gene polymorphisms (E298D and T-786C) in African-American SCD patients. The D298 allele showed no association; the C-786 allele showed a statistically significant association (P = 0.0061) in female ACS cases. Multiple...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anemia, Sickle Cell

Share to Nitric Oxide Synthase

Share to Nitric Oxide Synthase Type III

Share to Polymorphism, Genetic

Share to Sequence Analysis, DNA

Share to Syndrome

Source

Identifiers

PMID: 14687036
DOI: 10.1046/j.1365-2141.2003.04762.x

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of T-786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease.PMID 14687036Read ↗

Endothelial nitric oxide synthase gene polymorphisms and the risk of vasculopathy in sickle cell disease.Semantic proximity Read ↗

Association of endothelial nitric oxide synthase promoter region (T-786C) gene polymorphism with acute coronary syndrome and coronary heart disease.Semantic proximity Read ↗

Association between the - 786T>C 1polymorphism in the promoter region of endothelial nitric oxide synthase (eNOS) and risk of coronary artery disease: a systematic review and meta-analysis.Semantic proximity Read ↗

Prognostic value of T786C and G894T eNOS polymorphisms in sickle cell disease.Semantic proximity Read ↗

Impact of VEGFA -583C > T polymorphism on serum VEGF levels and the susceptibility to acute chest syndrome in pediatric patients with sickle cell disease.Semantic proximity Read ↗

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to PathophysiologySemantic proximity Read ↗

Genetic variants of the endothelial NO synthase gene (eNOS) may confer increased risk of sporadic congenital heart disease.Semantic proximity Read ↗

The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study.Semantic proximity Read ↗

Clinical relevance of eNOS T-786C polymorphism for hospital mortality and morbidity in cardiac surgical patients.Semantic proximity Read ↗

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology.Semantic proximity Read ↗

Multiple Thromboembolic Events in Young Patient with Homozygous T-786C Mutation in the Endothelial Nitric Oxide Synthase Gene (ENOS).Semantic proximity Read ↗

Association between the Glu298Asp and T(-786)C polymorphisms of the endothelial nitric oxide synthase gene and respiratory distress in preterm neonates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.