Article
NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.
The Journal of biological chemistry - 19 Mar 2004
Miyazaki Kou, Fujita Tomoyuki, Ozaki Toshinori, Kato Chiaki, Kurose Yuka, Sakamoto Maya, Kato Shinsuke, Goto Takeshi, Itoyama Yasuto, Aoki Masashi, Nakagawara Akira
Abstract excerpt
Approximately 20% of familial amyotrophic lateral sclerosis (FALS) arises from germ-line mutations in the superoxide dismutase-1 (SOD1) gene. However, the molecular mechanisms underlying the process have been elusive. Here, we show that a neuronal homologous to E6AP carboxyl terminus (HECT)-type ubiquitin-protein isopeptide ligase (NEDL1) physically binds translocon-associated protein-delta and also binds and...
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