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Article

Effects of Stuffer DNA on Transgene Expression from Helper-Dependent Adenovirus Vectors

1 Oct 1999

Abstract excerpt

We have analyzed transgene (lacZ) expression from a first-generation adenovirus (Ad) vector in comparison to helper-dependent (hd) Ads deleted for various portions of the viral coding sequences and generated by using the Cre/loxP helper-dependent system (R. J. Parks et al., Proc. Natl. Acad. Sci. USA 93:13565-13570, 1996). An hd vector deleted for approximately 70% of the Ad genome (AdRP1001) provided levels and...

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PMID: 10482551
DOI: 10.1128/jvi.73.10.8027-8034.1999

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