Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a.

1 Jan 2003

Abstract excerpt

Cyclooxygenase-2 (COX-2) is expressed early in colon carcinogenesis and is known to play a crucial role in the progress of the disease. Here we show that the regulation of the expression of this enzyme in a colon cancer cell line, and in patients, is associated with overexpression of the Wnt pathway-associated proteins, Pontin52/TIP49a and LEF-1. Recently shown to be essential for transformation via the c-Myc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen and related hormone effects
Share to Inflammatory mediators and NSAID effects
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14675489
DOI: 10.1186/1476-4598-2-42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a.PMID 14675489Read ↗

Targeting cyclooxygenase‐2 for prevention and therapy of colorectal cancerSemantic proximity Read ↗

Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal CancerSemantic proximity Read ↗

The role of COX-2 in intestinal cancer.Semantic proximity Read ↗

MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cellsSemantic proximity Read ↗

Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferationSemantic proximity Read ↗

A common single-nucleotide polymorphism in cyclooxygenase-2 disrupts microRNA-mediated regulation.Semantic proximity Read ↗

Regulation of Constitutive Cyclooxygenase-2 Expression in Colon Carcinoma CellsSemantic proximity Read ↗

Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance.Semantic proximity Read ↗

COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation statusSemantic proximity Read ↗

[Cyclooxygenase 2 and carcinogenesis].Semantic proximity Read ↗

Cyclooxygenase-2: a novel target for cancer chemotherapy?Semantic proximity Read ↗

Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.