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Article

COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status

13 Jun 2011

Abstract excerpt

BACKGROUND: Increased cyclooxygenase activity promotes progression of colorectal cancer, but the mechanisms behind COX-2 induction remain elusive. This study was therefore aimed to define external cell signaling and transcription factors relating to high COX-2 expression in colon cancer tissue. METHOD: Tumor and normal colon tissue were collected at primary curative operation in 48 unselected patients. COX-2...

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PMID: 21668942
DOI: 10.1186/1471-2407-11-238

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