Article
Enzymatic strategies for the characterization of nucleic acids by electrospray ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM - 1 Jan 2003
Null Allison P, Benson Linda M, Muddiman David C
Abstract excerpt
Electrospray ionization mass spectrometry (ESI-MS) is a powerful technique used for the identification and characterization of DNA polymorphisms. Continual improvement in instrument design assures high mass measurement accuracy, sensitivity, and resolving power. This work describes an eclectic array of enzymatic strategies we have invoked in order to detect single-nucleotide polymorphisms by ESI-MS, although...
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