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Article

4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells.

Journal of hepatology - 1 Jan 2004

Zamara Elena, Novo Erica, Marra Fabio, Gentilini Alessandra, Romanelli Roberto Giulio, Caligiuri Alessandra, Robino Gaia, Tamagno Elena, Aragno Manuela, Danni Oliviero, Autelli Riccardo, Colombatto Sebastiano, Dianzani Mario Umberto, Pinzani Massimo, Parola Maurizio

Abstract excerpt

BACKGROUND/AIMS: 4-Hydroxynonenal (HNE) is a putative pro-fibrogenic product of oxidative stress able to elicit apoptosis and cytotoxicity in several cell types. This study has been performed to evaluate its 'in vivo' levels in injured liver and whether HNE may induce apoptosis and/or affect selected phenotypic responses in activated human hepatic stellate cells (HSC/MF). METHODS/RESULTS: During the development...

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Identifiers

PMID: 14672615
DOI: 10.1016/s0168-8278(03)00480-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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