Targeting FLT3 for the treatment of leukemia.

doi:10.1053/j.seminhematol.2008.07.007

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Article

Targeting FLT3 for the treatment of leukemia.

Seminars in hematology - 1 Jul 2008

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Abstract excerpt

FLT3 is a receptor tyrosine kinase with important roles in hematopoietic stem/progenitor cell survival and proliferation. It is frequently overexpressed in acute leukemias and is frequently mutated in acute myeloid leukemia (AML). FLT3 internal tandem duplication (ITD) mutations in AML portend po...

Topics

Antibodies
Antineoplastic Combined Chemotherapy Protocols
Drug Delivery Systems
Gene Expression Regulation, Leukemic
Humans
Leukemia, Myeloid, Acute
Mutation
Protein Kinase Inhibitors
Treatment Outcome
fms-Like Tyrosine Kinase 3

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