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Article

Conformational effects of environmentally induced, cancer-related mutations in the p53 protein.

Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 1994

Brandt-Rauf P W, Monaco R, Pincus M R

Abstract excerpt

The tumor suppressor gene p53 has been identified as the most frequent target of genetic alterations in human cancers. A considerable number of environmentally induced, cancer-related p53 mutations in human tumors have been found in a highly conserved proline-rich sequence of the p53 protein encompassed by amino acid residues 147-158. Using conformational energy analysis based on ECEPP (Empirical Conformational...

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Identifiers

PMID: 7937752
DOI: 10.1073/pnas.91.20.9262
PMCID: PMC44792

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