Article
Does the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis?
Annals of the rheumatic diseases - 1 Nov 1992
Pile K D, Wordsworth B P, Bell J I
Abstract excerpt
There is a polygenic component to rheumatoid arthritis (RA) in addition to the known association with HLA-DR4. It has previously been shown in another autoimmune disease (type I diabetes mellitus) that a gene on chromosome 11p can act with HLA-DR4 to enhance susceptibility (relative risk 5-6). It is therefore possible that this locus may also affect the development of RA. Genotype frequencies at this locus,...
Topics
- Amino Acid Sequence
- Arthritis, Rheumatoid
- Chromosomes, Human, Pair 11
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Genes, MHC Class II
- Genotype
- HLA-DR4 Antigen
- Humans
- Molecular Sequence Data