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Article

Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer.

The Journal of biological chemistry - 20 Feb 2004

Gregory Christopher W, Fei Xiaoyin, Ponguta Liliana A, He Bin, Bill Heather M, French Frank S, Wilson Elizabeth M

Abstract excerpt

Growth of normal and neoplastic prostate is mediated by the androgen receptor (AR), a ligand-dependent transcription factor activated by high affinity androgen binding. The AR is highly expressed in recurrent prostate cancer cells that proliferate despite reduced circulating androgen. In this report, we show that epidermal growth factor (EGF) increases androgen-dependent AR transactivation in the recurrent...

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Source

Identifiers

PMID: 14662770
DOI: 10.1074/jbc.M307649200

Genes

EGF
GRIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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