Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

P-Glycoprotein Recognition of Substrates and Circumvention through Rational Drug Design

21 Dec 2005

Abstract excerpt

It is now well recognized that membrane efflux transporters, especially P-glycoprotein (P-gp; ABCB1), play a role in determining the absorption, distribution, metabolism, excretion, and toxicology behaviors of some drugs and molecules in development. An investment in screening structure-activity relationship (SAR) is warranted in early discovery when exposure and/or target activity in an in vivo efficacy model is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics Pharmacokinetics and Efficacy
Share to Drug Transport and Resistance Mechanisms
Share to Pharmacological Effects and Toxicity Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16686365
DOI: 10.1021/mp0500871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

P-Glycoprotein Recognition of Substrates and Circumvention through Rational Drug DesignPMID 16686365Read ↗

Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer TreatmentSemantic proximity Read ↗

Efflux Transporters and their Clinical RelevanceSemantic proximity Read ↗

The role of the efflux transporter, P‐glycoprotein, at the blood–brain barrier in drug discoverySemantic proximity Read ↗

Importance of P‐glycoprotein for drug disposition in humansSemantic proximity Read ↗

The Structure and Functions of P-GlycoproteinSemantic proximity Read ↗

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategySemantic proximity Read ↗

Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp)Semantic proximity Read ↗

Structure and function of efflux pumps that confer resistance to drugsSemantic proximity Read ↗

A Quantitative Approach for Assessing Multidrug Resistance in CancerSemantic proximity Read ↗

The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: future opportunities for structure-based drug design of inhibitorsSemantic proximity Read ↗

Future perspectives for the development of P-glycoprotein modulatorsSemantic proximity Read ↗

The translocation mechanism of P‐glycoproteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.