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Article

Retinal Degeneration Progression Changes Lentiviral Vector Cell Targeting in the Retina

25 Aug 2011

Abstract excerpt

In normal mice, the lentiviral vector (LV) is very efficient to target the RPE cells, but transduces retinal neurons well only during development. In the present study, the tropism of LV has been investigated in the degenerating retina of mice, knowing that the retina structure changes during degeneration. We postulated that the viral transduction would be increased by the alteration of the outer limiting...

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PMID: 21901134
DOI: 10.1371/journal.pone.0023782

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