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Article

Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity.

The Journal of biological chemistry - 20 Feb 2004

Barzilay Eran, Ben-Califa Nathalie, Supino-Rosin Lia, Kashman Yoel, Hirschberg Koret, Elazar Zvulun, Neumann Drorit

Abstract excerpt

Geldanamycin, an ansamycin antibiotic that specifically inhibits heat-shock protein-90 (HSP90) and its endoplasmic reticulum homologue, glucose-regulated protein-94 (GRP94), accelerates the degradation of selected cellular proteins. We showed previously that geldanamycin inhibits maturation and transport of the epidermal growth factor receptor in addition to accelerating its degradation (Supino-Rosin, L.,...

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PMID: 14660597
DOI: 10.1074/jbc.M312799200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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