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Article

Geldanamycin, a heat shock protein 90-binding agent, disrupts Stat5 activation in IL-2-stimulated cells.

Journal of cellular physiology - 1 Feb 2004

Xu Weijing, Yu Furong, Yan Mingda, Lu Linrong, Zou Weiguo, Sun Lanying, Zheng Zhongcheng, Liu Xinyuan

Abstract excerpt

The 90-kDa heat shock protein (Hsp90) is the most abundant molecular chaperone in eukaryotic cells. Hsp90 plays a critical role in regulating signal transduction pathways that control cell proliferation since its chaperone function is restricted to a subset of proteins including some signal molecules. Improper function of these proteins can be induced by an anti-tumor agent geldanamycin (GA) which is the specific...

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PMID: 14603521
DOI: 10.1002/jcp.10403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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