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Article

Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives.

Cancer research - 1 Aug 2008

Fukuyo Yayoi, Inoue Masahiro, Nakajima Takuma, Higashikubo Ryuji, Horikoshi Nobuko T, Hunt Clayton, Usheva Anny, Freeman Michael L, Horikoshi Nobuo

Abstract excerpt

The geldanamycin derivatives 17-allylamino-17-demethoxygeldanamycin (17-AAG) and 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) are promising chemotherapeutic drugs that inhibit heat shock protein 90 (HSP90) function. Previous studies have shown that 17-AAG/DMAG treatment induces the degradation of mutant BRAF (V600E) and inhibits the activation of mitogen-activated protein/extracellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18676857
DOI: 10.1158/0008-5472.CAN-07-6602
PMCID: PMC2693332

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives.PMID 18676857Read ↗

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