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Article

The disulfide bonding pattern in ficolin multimers.

The Journal of biological chemistry - 20 Feb 2004

Ohashi Tomoo, Erickson Harold P

Abstract excerpt

Ficolin is a plasma lectin, consisting of a short N-terminal multimerization domain, a middle collagen domain, and a C-terminal fibrinogen-like domain. The collagen domains assemble the subunits into trimers, and the N-terminal domain assembles four trimers into 12-mers. Two cysteine residues in the N-terminal domain are thought to mediate multimerization by disulfide bonding. We have generated three mutants of...

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PMID: 14660572
DOI: 10.1074/jbc.M310555200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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