Article
Coexisting well-differentiated and anaplastic thyroid carcinoma in the same primary resection specimen: immunophenotypic and genetic comparison of the two components in a consecutive series of 13 cases and a review of the literature.
Virchows Archiv : an international journal of pathology - 1 Feb 2021
Ragazzi Moira, Torricelli Federica, Donati Benedetta, Ciarrocchi Alessia, de Biase Dario, Tallini Giovanni, Zanetti Eleonora, Bisagni Alessandra, Kuhn Elisabetta, Giordano Davide, Frasoldati Andrea, Piana Simonetta
Abstract excerpt
Anaplastic carcinoma (AC) is a rare but highly aggressive form of thyroid cancer. It mostly arises on a background of pre-existing well-differentiated cancer (WDC); however, whether it evolves directly from a WDC or originates as a second independent neoplasm is still to be defined. To obtain further insights into these mechanisms, we performed morphological, immunohistochemical, and next-generation sequencing...
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