Article
Anaplastic transformation of thyroid cancer: review of clinical, pathologic, and molecular evidence provides new insights into disease biology and future therapy.
Head & neck - 1 Aug 2003
Wiseman Sam M, Loree Thom R, Rigual Nestor R, Hicks Wesley L, Douglas Wade G, Anderson Garth R, Stoler Daniel L
Abstract excerpt
BACKGROUND: Anaplastic thyroid cancer ranks among the most lethal of all human malignancies. Its rarity and rapidly fatal course have made it a difficult cancer to both study and treat. Unfortunately, there has been little progress in the management and control of this malignancy. Anaplastic transformation, or the intratumoral evolution of anaplastic carcinoma from pre-existing differentiated thyroid cancer, has...
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