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Article

Functional link between Myc and the Werner gene in tumorigenesis.

Cell cycle (Georgetown, Tex.) - 1 Jan 2004

Grandori Carla, Robinson Kristin L, Galloway Denise A, Swisshelm Karen

Abstract excerpt

We have recently reported a connection between the expression of the Werner syndrome gene (WRN), whose loss of function has been implicated in a human progeroid syndrome (WS), and the Myc oncoprotein. Myc overexpression directly elevates trancription of the WRN gene, whose presence is required to avoid senescence during Myc proliferative stimuli. Here we discuss several hypotheses to explain why WRN might be...

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Source

Identifiers

PMID: 14657658

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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