Article
Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein.
Science (New York, N.Y.) - 5 Dec 2003
Willingham Stephen, Outeiro Tiago Fleming, DeVit Michael J, Lindquist Susan L, Muchowski Paul J
Abstract excerpt
Genome-wide screens were performed in yeast to identify genes that enhance the toxicity of a mutant huntingtin fragment or of alpha-synuclein. Of 4850 haploid mutants containing deletions of nonessential genes, 52 were identified that were sensitive to a mutant huntingtin fragment, 86 that were sensitive to alpha-synuclein, and only one mutant that was sensitive to both. Genes that enhanced toxicity of the mutant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.