Article
Fosmid-based whole genome haplotyping of a HapMap trio child: evaluation of Single Individual Haplotyping techniques.
Nucleic acids research - 1 Mar 2012
Duitama Jorge, McEwen Gayle K, Huebsch Thomas, Palczewski Stefanie, Schulz Sabrina, Verstrepen Kevin, Suk Eun-Kyung, Hoehe Margret R
Abstract excerpt
Determining the underlying haplotypes of individual human genomes is an essential, but currently difficult, step toward a complete understanding of genome function. Fosmid pool-based next-generation sequencing allows genome-wide generation of 40-kb haploid DNA segments, which can be phased into c...
Topics
- Algorithms
- Genome, Human
- Genomics
- HapMap Project
- Haplotypes
- High-Throughput Nucleotide Sequencing
- Humans
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA