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Article

Fosmid-based whole genome haplotyping of a HapMap trio child: evaluation of Single Individual Haplotyping techniques.

Nucleic acids research - 1 Mar 2012

Duitama Jorge, McEwen Gayle K, Huebsch Thomas, Palczewski Stefanie, Schulz Sabrina, Verstrepen Kevin, Suk Eun-Kyung, Hoehe Margret R

Abstract excerpt

Determining the underlying haplotypes of individual human genomes is an essential, but currently difficult, step toward a complete understanding of genome function. Fosmid pool-based next-generation sequencing allows genome-wide generation of 40-kb haploid DNA segments, which can be phased into contiguous molecular haplotypes computationally by Single Individual Haplotyping (SIH). Many SIH algorithms have been...

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Identifiers

PMID: 22102577
DOI: 10.1093/nar/gkr1042
PMCID: PMC3299995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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