Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms within the vitamin B12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects.

Molecular genetics and metabolism - 1 Dec 2003

Parle-McDermott Anne, McManus Edward J, Mills James L, O'Leary Valerie B, Pangilinan Faith, Cox Christopher, Weiler Andrea, Molloy Anne M, Conley Mary, Watson Deborah, Scott John M, Brody Lawrence C, Kirke Peadar N

Abstract excerpt

Methionine synthase and methylmalonyl-CoA mutase (mutase) are the only two known vitamin B(12) (B(12)) dependent enzymes in humans. A lower level of B(12) has been shown to be an independent maternal risk factor for neural tube defects (NTDs) prompting an investigation of common genetic variants within B(12) dependent enzymes. To investigate the role of methylmalonyl-CoA mutase variants we studied 279 complete...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child, Preschool
Share to Linear Models

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

Share to Methylmalonyl-CoA Mutase

Share to Neural Tube Defects

Share to Pedigree

Share to Racial Groups

Share to Vitamin B 12

Source

Identifiers

PMID: 14654360
DOI: 10.1016/j.ymgme.2003.09.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms within the vitamin B12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects.PMID 14654360Read ↗

Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association.Semantic proximity Read ↗

Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida.Semantic proximity Read ↗

A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida.Semantic proximity Read ↗

Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population.Semantic proximity Read ↗

Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts?Semantic proximity Read ↗

Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate‐dehydrogenase, methenyltetrahydrofolate‐cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defectsSemantic proximity Read ↗

Analysis of the human folate receptor beta gene for an association with neural tube defects.Semantic proximity Read ↗

Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects.Semantic proximity Read ↗

Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida.Semantic proximity Read ↗

Altered folate and vitamin B12 metabolism in families with spina bifida offspringSemantic proximity Read ↗

C677T polymorphism of the methylenetetrahydrofolate reductase gene does not affect folic acid, vitamin B12, and homocysteine serum levels in Turkish children with neural tube defects.Semantic proximity Read ↗

Is the common 677C-->T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.