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Article

mtDNA mutations in tumors of the central nervous system reflect the neutral evolution of mtDNA in populations.

Oncogene - 12 Feb 2004

Vega Ana, Salas Antonio, Gamborino Elena, Sobrido María Jesús, Macaulay Vincent, Carracedo Angel

Abstract excerpt

Mitochondrial DNA (mtDNA) instability has been observed in different types of cancer, including colorectal, breast, and gastric cancer. The relationship between the occurrence of such alteration and the nuclear microsatellite instability (nMI) status of the neoplastic cells remains controversial. In an attempt to clarify this issue, we sequenced the first and second mtDNA hypervariable regions, and typed the...

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Identifiers

PMID: 14647457
DOI: 10.1038/sj.onc.1207214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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