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Article

Human telomerase reverse transcriptase immortalizes bovine lens epithelial cells and suppresses differentiation through regulation of the ERK signaling pathway.

The Journal of biological chemistry - 17 Jun 2005

Wang Juan, Feng Hao, Huang Xiao-Qin, Xiang Hua, Mao Ying-Wei, Liu Jin-Ping, Yan Qin, Liu Wen-Bin, Liu Yan, Deng Mi, Gong Lili, Sun Shuming, Luo Chen, Liu Shao-Jun, Zhang Xuan-Jie, Liu Yun, Li David Wan-Cheng

Abstract excerpt

Telomerase is a specialized reverse transcriptase that extends telomeres of eukaryotic chromosomes. The functional telomerase complex contains a telomerase reverse transcriptase catalytic subunit and a telomerase template RNA. We have previously demonstrated that human telomerase reverse transcriptase (hTERT) catalytic subunit is functionally compatible with a telomerase template RNA from rabbit. In this study,...

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Identifiers

PMID: 15849192
DOI: 10.1074/jbc.M500032200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Human telomerase reverse transcriptase immortalizes bovine lens epithelial cells and suppresses differentiation through regulation of the ERK signaling pathway.PMID 15849192Read ↗

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