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Article

Ubiquitin depletion as a key mediator of toxicity by translational inhibitors.

Molecular and cellular biology - 1 Dec 2003

Hanna John, Leggett David S, Finley Daniel

Abstract excerpt

Cycloheximide acts at the large subunit of the ribosome to inhibit translation. Here we report that ubiquitin levels are critical for the survival of Saccharomyces cerevisiae cells in the presence of cycloheximide: ubiquitin overexpression confers resistance to cycloheximide, while a reduced ubiquitin level confers sensitivity. Consistent with these findings, ubiquitin is unstable in yeast (t(1/2) = 2 h) and is...

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Identifiers

PMID: 14645527
DOI: 10.1128/MCB.23.24.9251-9261.2003
PMCID: PMC309641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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