Article
An integrated model system to gain mechanistic insights into biofilm-associated antimicrobial resistance in Pseudomonas aeruginosa MPAO1.
NPJ biofilms and microbiomes - 30 Oct 2020
Varadarajan Adithi R, Allan Raymond N, Valentin Jules D P, Castañeda Ocampo Olga E, Somerville Vincent, Pietsch Franziska, Buhmann Matthias T, West Jonathan, Skipp Paul J, van der Mei Henny C, Ren Qun, Schreiber Frank, Webb Jeremy S, Ahrens Christian H
Abstract excerpt
Pseudomonas aeruginosa MPAO1 is the parental strain of the widely utilized transposon mutant collection for this important clinical pathogen. Here, we validate a model system to identify genes involved in biofilm growth and biofilm-associated antibiotic resistance. Our model employs a genomics-driven workflow to assemble the complete MPAO1 genome, identify unique and conserved genes by comparative genomics with...
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