Article
A large AZFc deletion removes DAZ3/DAZ4 and nearby genes from men in Y haplogroup N.
American journal of human genetics - 1 Jan 2004
Fernandes S, Paracchini S, Meyer L H, Floridia G, Tyler-Smith C, Vogt P H
Abstract excerpt
Deletion of the entire AZFc locus on the human Y chromosome leads to male infertility. The functional roles of the individual gene families mapped to AZFc are, however, still poorly understood, since the analysis of the region is complicated by its repeated structure. We have therefore used single-nucleotide variants (SNVs) across approximately 3 Mb of the AZFc sequence to identify 17 AZFc haplotypes and have...
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