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Article

Major depression and associated impairment: same or different genetic and environmental risk factors?

The American journal of psychiatry - 1 Dec 2003

Foley Debra L, Neale Michael C, Gardner Charles O, Pickles Andrew, Prescott Carol A, Kendler Kenneth S

Abstract excerpt

OBJECTIVE: Impairment was added as a diagnostic criterion for many psychiatric disorders in DSM-IV. Does the addition of impairment influence only prevalence rates, or does it also introduce new etiological factors into psychiatric diagnoses? METHOD: A lifetime history of major depression and associated functional impairment was assessed by personal interview with 3,669 female and 4,377 male twins from the...

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PMID: 14638582
DOI: 10.1176/appi.ajp.160.12.2128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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