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Article

PARP cleavage, DNA fragmentation, and pyknosis during excitotoxin-induced neuronal death.

Experimental neurology - 1 Nov 2003

Gilliams-Francis Karen L, Quaye Aurora A, Naegele Janice R

Abstract excerpt

Poly(ADP-ribose)polymerase-1 (PARP-1) is a nuclear enzyme activated by DNA breaks and serves a role in DNA repair through the formation of polymers (poly(ADP)ribosylation) at sites of DNA damage. PARP-1 is activated by DNA damage in neurons of the hippocampus and cerebral cortex following excessive exposure to glutamate receptor agonists such as NMDA or kainic acid. In addition, recent studies suggest that...

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PMID: 14637106
DOI: 10.1016/j.expneurol.2003.07.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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