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Article

The VCAM-1 gene that encodes the vascular cell adhesion molecule is a target of the Sry-related high mobility group box gene, Sox18.

The Journal of biological chemistry - 13 Feb 2004

Hosking Brett M, Wang S-C Mary, Downes Meredith, Koopman Peter, Muscat George E O

Abstract excerpt

VCAM-1 (vascular cell adhesion molecule-1) and Sox18 are involved in vascular development. VCAM-1 is an important adhesion molecule that is expressed on endothelial cells and has a critical role in endothelial activation, inflammation, lymphatic pathophysiology, and atherogenesis. The Sry-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14634005
DOI: 10.1074/jbc.M308512200

Genes

SOX18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14634005-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The VCAM-1 gene that encodes the vascular cell adhesion molecule is a target of the Sry-related high mobility group box gene, Sox18.PMID 14634005Read ↗

Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturationSemantic proximity Read ↗

Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.Semantic proximity Read ↗

Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice.Semantic proximity Read ↗

Sox18 and Sox7 play redundant roles in vascular development.Semantic proximity Read ↗

SOX18 directly interacts with MEF2C in endothelial cells.Semantic proximity Read ↗

Aortic Dilatation Associated With a De Novo Mutation in the SOX18 Gene: Expanding the Clinical Spectrum of Hypotrichosis-Lymphedema-Telangiectasia Syndrome.Semantic proximity Read ↗

Inhibition of tumor angiogenesis by cell-permeable dominant negative SOX18 mutants.Semantic proximity Read ↗

Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafish.Semantic proximity Read ↗

VEGFD regulates blood vascular development by modulating SOX18 activitySemantic proximity Read ↗

Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling.Semantic proximity Read ↗

Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in ZebrafishSemantic proximity Read ↗

Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene.Semantic proximity Read ↗

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