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Article

Multiple myeloma cells expressing low levels of CD138 have an immature phenotype and reduced sensitivity to lenalidomide.

International journal of oncology - 1 Sept 2012

Kawano Yawara, Fujiwara Shiho, Wada Naoko, Izaki Mikiko, Yuki Hiromichi, Okuno Yutaka, Iyama Kenichi, Yamasaki Hiroshi, Sakai Akira, Mitsuya Hiroaki, Hata Hiroyuki

Abstract excerpt

CD138 expression is a hallmark of plasma cells and multiple myeloma cells. However, decreased expression of CD138 is frequently observed in plasma cells of myeloma patients, although the clinical significance of this is unclear. To evaluate the significance of low expression of CD138 in MM, we examined the phenotypes of MM cells expressing low levels of CD138. Flow...

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Source

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Identifiers

PMID: 22766978
DOI: 10.3892/ijo.2012.1545
PMCID: PMC3582943

Genes

BCL6
PAX5
PRDM1
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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