Article
Phenotypic identification of subclones in multiple myeloma with different chemoresistant, cytogenetic and clonogenic potential.
Leukemia - 1 May 2015
Paíno T, Paiva B, Sayagués J M, Mota I, Carvalheiro T, Corchete L A, Aires-Mejía I, Pérez J J, Sanchez M L, Barcena P, Ocio E M, San-Segundo L, Sarasquete M E, García-Sanz R, Vidriales M-B, Oriol A, Hernández M-T, Echeveste M-A, Paiva A, Blade J, Lahuerta J-J, Orfao A, Mateos M-V, Gutiérrez N C, San-Miguel J F
Abstract excerpt
Knowledge about clonal diversity and selection is critical to understand multiple myeloma (MM) pathogenesis, chemoresistance and progression. If targeted therapy becomes reality, identification and monitoring of intraclonal plasma cell (PC) heterogeneity would become increasingly demanded. Here we investigated the kinetics of intraclonal heterogeneity among 116 MM patients using 23-marker multidimensional flow...
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