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Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity.

Journal of cell science - 1 Oct 1999

Arellano M, Valdivieso M H, Calonge T M, Coll P M, Duran A, Perez P

Abstract excerpt

Schizosaccharomyces pombe rho1(+) is required for maintenance of cell integrity and polarization of the actin cytoskeleton. However, no other effector besides the (1,3)beta-D-glucan synthase enzyme has been identified in S. pombe. We have further investigated if rho1(+ )signalling could be also mediated by the two protein kinase C homologues, pck1p and pck2p. We show in this study that both kinases interact with...

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PMID: 10504305
DOI: 10.1242/jcs.112.20.3569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity.PMID 10504305Read ↗

Activation of the cell integrity pathway is channelled through diverse signalling elements in fission yeast.Semantic proximity Read ↗

Localisation of the Schizosaccharomyces pombe rho1p GTPase and its involvement in the organisation of the actin cytoskeleton.Semantic proximity Read ↗

Fission yeast protein kinase C gene homologues are required for protoplast regeneration: a functional link between cell wall formation and cell shape control.Semantic proximity Read ↗

Overactivation of the protein kinase C-signaling pathway suppresses the defects of cells lacking the Rho3/Rho4-GAP Rgd1p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rho 1 GTPase activates the (1-3)beta-D-glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis.Semantic proximity Read ↗

KlRHO1 and KlPKC1 are essential for cell integrity signalling in Kluyveromyces lactis.Semantic proximity Read ↗

Rho1p, a yeast protein at the interface between cell polarization and morphogenesis.Semantic proximity Read ↗

Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe.Semantic proximity Read ↗

Schizosaccharomyces pombe Rgf3p is a specific Rho1 GEF that regulates cell wall beta-glucan biosynthesis through the GTPase Rho1p.Semantic proximity Read ↗

The Rho1p exchange factor Rgf1p signals upstream from the Pmk1 mitogen-activated protein kinase pathway in fission yeast.Semantic proximity Read ↗

The PH domain of the yeast GEF Rom2p serves an essential function in vivo.Semantic proximity Read ↗

Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast.Semantic proximity Read ↗

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