An intramolecular DNA triplex is disrupted by point mutations associated with hereditary persistence of fetal hemoglobin.

Abstract excerpt

Several investigators have suggested that secondary structures in DNA may be involved with physiologic gene regulatory processes in higher organisms. This hypothesis has been difficult to prove, however, since naturally occurring mutations that alter secondary DNA structures have not yet been ide...

Topics

• Base Sequence
• DNA
• DNA, Superhelical
• Fetal Hemoglobin
• Globins
• Hemoglobinopathies
• Hydrogen-Ion Concentration
• Molecular Sequence Data
• Mutation
• Nucleic Acid Conformation
• Plasmids