Article
Site stripping based on likelihood ratio reduction is a useful tool to evaluate the impact of non-clock-like behavior on viral phylogenetic reconstructions.
FEMS immunology and medical microbiology - 28 Nov 2003
Lemey Philippe, Salemi Marco, Wang Bin, Duffy Margaret, Hall William H, Saksena Nitin K, Vandamme Anne Mieke
Abstract excerpt
The site stripping for clock detection procedure was implemented in the recently developed maximum likelihood framework for estimating evolutionary rates and divergence times in measurably evolving populations. The method was used to investigate the effect of rate variability on estimating divergence times in non-clock-like trees for human immunodeficiency viruses and hepatitis C viruses. We validate our approach...
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