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Birth–death skyline plot reveals temporal changes of epidemic spread in HIV and hepatitis C virus (HCV)

17 Dec 2012

Abstract excerpt

Phylogenetic trees can be used to infer the processes that generated them. Here, we introduce a model, the bayesian birth-death skyline plot, which explicitly estimates the rate of transmission, recovery, and sampling and thus allows inference of the effective reproductive number directly from genetic data. Our method allows these parameters to vary through time in a piecewise fashion and is implemented within...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23248286
DOI: 10.1073/pnas.1207965110

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