Article
A method to correct for the effects of purifying selection on genealogical inference.
Molecular biology and evolution - 1 Oct 2010
O'Fallon Brendan D
Abstract excerpt
Accurate reconstruction of the divergence times among individuals is an essential step toward inferring population parameters from genetic data. However, our ability to reconstruct accurate genealogies is often thwarted by the evolutionary forces we hope to detect, most prominently natural selection. Here, I demonstrate that purifying selection acting at many linked sites can systematically bias current methods...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
