Article
The influence of rate heterogeneity among sites on the time dependence of molecular rates.
Molecular biology and evolution - 1 Nov 2012
Soubrier Julien, Steel Mike, Lee Michael S Y, Der Sarkissian Clio, Guindon Stéphane, Ho Simon Y W, Cooper Alan
Abstract excerpt
Molecular evolutionary rate estimates have been shown to depend on the time period over which they are estimated. Factors such as demographic processes, calibration errors, purifying selection, and the heterogeneity of substitution rates among sites (RHAS) are known to affect the accuracy with which rates of evolution are estimated. We use mathematical modeling and Bayesian analyses of simulated sequence...
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