Article
Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors.
Metabolism: clinical and experimental - 1 Nov 2003
Pauciullo Paolo, Giannino Alessandro, De Michele Mario, Gentile Marco, Liguori Rosario, Argiriou Anagnostis, Carlotto Alessandra, Faccenda Fulvio, Mancini Mario, Bond M Gene, De Simone Vincenzo, Rubba Paolo
Abstract excerpt
The current study sought to investigate the role of low-density lipoprotein receptor (LDLr) mutations in assessing the risk profile of familial hypercholesterolemia (FH) patients, independently of major cardiovascular risk factors. FH due to LDLr mutations is associated with premature atherosclerosis. The variable clinical severity of the disease in heterozygotes has been related to cholesterol levels and the...
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