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Article

The contribution of proline 250 (P-2') to pore diameter and ion selectivity in the human glycine receptor channel.

Neuroscience letters - 20 Nov 2003

Lee David J-S, Keramidas Angelo, Moorhouse Andrew J, Schofield Peter R, Barry Peter H

Abstract excerpt

The glycine receptor-channel (GlyR) mediates neuronal inhibition by selectively allowing the passage of Cl(-) ions through its channel. The pore region for ion selectivity is localised to the constricted internal end of the M2 transmembrane domain. This paper investigates the contribution of the P-2' residue in determining pore diameter and ion charge selectivity of the GlyR. The deletion of this proline has been...

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Identifiers

PMID: 14623139
DOI: 10.1016/j.neulet.2003.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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