Article
Association of the polymorphisms in the 5'-untranslated region of PTEN gene with type 2 diabetes in a Japanese population.
FEBS letters - 20 Nov 2003
Ishihara Hajime, Sasaoka Toshiyasu, Kagawa Syota, Murakami Shihou, Fukui Kazuhito, Kawagishi Yukio, Yamazaki Katsuya, Sato Akira, Iwata Minoru, Urakaze Masaharu, Ishiki Manabu, Wada Tsutomu, Yaguchi Saori, Tsuneki Hiroshi, Kimura Ikuko, Kobayashi Masashi
Abstract excerpt
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known to act as a lipid phosphatase hydrolyzing phosphatidylinositol (PI)(3,4,5)P(3) to PI(4,5)P(2). Since the PI3-kinase product, PI(3,4,5)P(3), is an important second messenger leading to the metabolic action of insulin, PTEN functions as a potent negative regulator of insulin signaling and its gene is one of the possible candidates involved in...
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